TABLE 1.

Angiogenesis and miRs

Pro-angiogenic miRs	Target gene	Ref.
miR-9	SOCS5	Zhuang et al. (2012)
miR-10a	MAP3K7; HOXA1; bTRC	Fang et al. (2010)
miR-21	STAT3	Liu et al. (2015)
miR-23/27	SEMA6A; SPROUTY2	Zhou et al. (2011a)
miR-107	DICER1	Li et al. (2015)
miR-126	PI3KR2; SPRED1;VCAM1; SDF1	Nicoli et al. (2010)
miR-130	HOXA5, GAX	Li et al. (2015)
miR-132/212	RASA1, SPRED2	Lei et al. (2015)
miR-210	EFNA3	Wang et al. (2013)
miR-217	SIRT1- FOXO/eNOS	Menghini et al. (2009)
miR-424	HIF-1α	Kim et al. (2013)
miR891a-5p	NF-κB	Yao et al. (2015)
Anti-angiogenic miRs
miR-17	JAK-1	Katz et al. (2014)
miR-21	RhoB;PPARγ	Zhou et al. (2011b)
miR-24	GATA-2; PAK4	Zhou et al. (2014)
miR-92a	SIRT1; ITGA5; KLF4 and MKK4	Ohyagi-Hara et al. (2013)
miR-200	Ets-1; IL-8; CXCL1	Chan et al. (2011)
miR-221/222	STA5a; c-KIT; eNOS	Nicoli et al. (2012)
miR-492	eNOS	Patella et al. (2013)
14q32 miR cluster (329, 487b, 494, 495)	Multiple neovascularization genes	Welten et al. (2014)
miR-497	VEGFR2	Tu et al. (2015)
miR-505	FGF18	Yang et al. (2014)
miR-506	SPHK1	Lu et al. (2015)

EFNA3, Ephrin-A3; eNOS, Endothelial Nitric Oxide Synthase; FGF18, Fibroblast growth factor 18; JAK1, Janus kinase 1; KLF4, Kruppel-like factor 4; PPAR-γ, Peroxisome proliferator-activated receptor gamma; RhoB, Ras homolog gene family, member B; SIRT1, sirtuin (silent mating type information regulation 2 homolog) 1; SOCS5, suppressor of cytokine signaling 5; PI3KR2, phosphoinositol-3 kinase regulatory subunit 2; RASA1, RAS p21 protein activator; SPRED2, sprouty-related, EVH1 domain containing 1; SEMA6A, Semaphorin-6A; SPHK1, sphingosine kinase 1; STAT3, Signal transducer and activator of transcription 3; VCAM-1, vascular cell adhesion molecule 1; VEGFR2, vascular endothelial growth factor receptor 2.