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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: J Immunol. 2015 Jul 1;195(4):1377–1387. doi: 10.4049/jimmunol.1302874

FIGURE 2.

FIGURE 2

CD151 deficiency leads to enhanced late phase of FcεRI-mediated PCA. (A) WT and CD151−/− mice were sensitized passively by an intradermal injection with 100 ng IgE into the right ear and saline into the left ear as a control. After 24 h, mice were challenged retro-orbitally with 100 μg DNP-HSA. Ear swelling was measured at each time point shown (mean ± SEM, n = 5 mice/group). The DNP-HSA–induced increase in ear thickness was measured as the Δ difference from thickness of the same mouse control ears injected with saline. At 24–36 h, a significant increase in IgE-induced ear thickness was observed in CD151−/− mice compared with WT mice (*p < 0.05). This experiment was repeated three times. (B) Mast cells were quantified by histology in 4-μm paraffin sections of ear tissue stained by toluidine blue. HPF, high-powered field.