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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: J Immunol. 2015 Jul 1;195(4):1377–1387. doi: 10.4049/jimmunol.1302874

FIGURE 7.

FIGURE 7

CD151 negatively regulates cytokine production in activated BMMCs by inhibiting ERK and PI3K pathway activation. BMMCs were unprimed or primed with IgE, then exposed to 100 ng/ml DNP-HSA for 24 h in the absence or presence of 10 μM LY294002 (LY), 100 nM Wortmannin (W), 10 μM PD98056 (PD) or DMSO vehicle control. NS, not stimulated controls. IL-4, IL-13, and TNF-α cytokine release by BMMCs was measured in culture supernatants by ELISA. Results shown are the mean ± SEM of three determinations. Filled columns indicate WT; open columns indicate CD151−/−. *p < 0.05.