Table 1.

Overview of changes in gene expression in RAW264.7 cells upon C646 (at 30 μM) or SAHA (at 0.41 μM) pre-treatment, as well as in PCLS upon C646 (at 25 μM) or SAHA (at 0.41 μM) pre-treatment followed by an inflammatory LPS and IFNγ stimulus. The percentage of change compared to vehicle treatment is indicated. Upreguation is indicated by ↑, downregulation by ↓, and no effect by –. N.E. = gene is not expressed, and N.D. = gene expression was not determined.

C646	TNFα	iNOS	IL-1β	IL-6	IL-8	IL-12b
RAW264.7	↓ (54.1 %)	-	-	-	N.E.	↓ (54.2 %)
PCLS	↓ (79.1 %)	↓ (58.4 %)	↓ (72.3 %)	-	-	↓ (85.0 %)
SAHA	TNFα	iNOS	IL-1β	IL-6	IL-8	IL-12b
RAW264.7	-	-	↑ (317 %)	N.D.	N.E.	-
PCLS	-	↓ (39.9 %)	↑ (41.5 %)	↑ (58.8 %)	N.D.	-