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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Nature. 2015 Sep 16;526(7571):118–121. doi: 10.1038/nature15373

Figure 3. Adherence to damaged human and rodent vasculatures.

Figure 3

(a) H&E-stained cross-sections of undamaged (top) and damaged (bottom) human carotid arteries. Scale bar = 200 µm. (b) Fluorescence images of the cross-section (scale bar = 200 µm) and (c) the luminal side (scale bar = 500 µm) of undamaged (top) and damaged (bottom) arteries following PNP incubation (tissue in green and PNPs in red). (d,e) 3D reconstructed images of intact (top) and balloon-denuded (bottom) arterial walls from multisectional images following intravenous administration of PNPs in rats (cell nuclei in blue and PNPs in red). Dimensions: 152.5 µm × 116 µm × 41 µm. (f) Retention of PNPs at the denuded and the intact arteries over 120 h following PNP administration (n=6). (g) Representative H&E-stained arterial cross-sections from different treatment groups in a rat model of coronary restenosis. Scale bar = 200 µm (h) Zoomed-in H&E-stained arterial cross-sections highlight the different vascular remodeling from the different treatment groups. I, intima; M, media. Scale bar = 100 µm. (i,j) Quantitative analysis of intima-to-media area ratio and luminal obliteration from the different treatment groups (n=6). All bars represent means ± SD. NS = no statistical significance.