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. 2016 May 18;11(5):e0155799. doi: 10.1371/journal.pone.0155799

Fig 5. GGA3KO mice display deficits in GABAergic tonic current.

Fig 5

Recordings were made from DGGCs in hippocampal slices from 6–8 week-old GGA3WT and GGA3KO mice in the presence of 1μM GABA. Tonic current was determined by measuring the difference in holding current amplitude before and after applying 100 μM picrotoxin (PTX). GGA3KO mice exhibited a significant reduction in tonic current amplitude (A). The graph represents mean ± SEM of current amplitude and density (B). * = significantly different to control (p<0.05; t-test, n = 7–8 cells, from 3 animal for genotype).