Table 2. Clinical and pathologic variables and measured tissue platinum concentration stratified by pathologic stage.

Sex	Clinical stage	Histology	NAC agents	NAC cycles	Pathologic stage	Pt concentration (AU/mg): Benign urothelium	Pt concentration (AU/mg): Tumor
F	cT2N0M0	HG papillary UC	GC	2	ypT0N0	0.003329412	n/a
F	cT2N2M0	HG papillary UC	GC	4	ypT0N0	0.002541	n/a
M	cT2N0M0	UC	GC	3	ypT0N0	0.00835	n/a
M	cT2N0M0	small cell carcioma	cis-etoposide	3	ypT0N0	0.006623077	n/a
F	cT2N0M0	HG papillary UC	GC	3	ypTisN0	0.001942222	n/a
M	cT2N0M0	HG papillary UC, focal SqD	MVAC and GC	4	ypTisN0	0.001546667	n/a
F	cT4N0M0	HG papillary UC	MVAC	4	ypTaN0	0.000561538	0.000783871
M	cT2N0M0	HG papilary UC	GC	3	ypT1N0	0.00215625	0.001322727
M	cT2N0M0	HG papillary UC	G-carbo	3	ypTisN1	0.002039	n/a
F	cT2N0M0	UC	GC	3	ypTisN2	0.001169	n/a
F	cT2N0M0	UC	GC	2	ypT2aN0	0.001466667	0
M	cT2N0M0	HG papillary UC	GC	4	ypT2aN0	0.000836364	0.001658824
M	cT2N0M0	UC	GC	3	ypT3aN0	0.00213913	0
M	cT2N0M0	HG papillary UC	GC	4	ypT2bN1	0.00328511	n/a
M	cT2N0M0	UC	cis-?	3	ypT3N1	0.001234211	0.000260465
F	cT2N0M0	UC, mixed nested variant	GC	3	ypT3aN1	0.0025	n/a
M	cT2N0M0	HG papillary UC, focal SqD	GC	3	ypT3aN1	0.002963415	0.000641176
M	cT2N0M1	UC, focal micopapillary	MVAC	4	ypT4N1	0.002619	n/a
M	cT2N0M0	HG papillary UC	GC	4	ypT4N2	0.001093333	0

Abbreviations: AU/mg, absorbance units divided by milligram of tissue; carbo, carboplatin; cis, cisplatin; F, female; GC, gemcitabine, cisplatin; G-carbo, gemcitabine, carboplatin; HG, high grade; M, male; MVAC, methotrexate, vinblastine, adriamycin, cisplatin; n/a, not available; NAC, neoadjuvant chemotherapy; Pt, platinum; SqD, squamous differentiation; TURBT, transurethral resection of bladder tumor; UC, urothelial carcinoma.