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. 2016 May 17;12(5):e1004915. doi: 10.1371/journal.pcbi.1004915

Fig 4. Geodesic boundary leads to the Quasi-Steady-State Approximation.

Fig 4

By promoting the initial conditions E0 and S0 to parameters, the geodesics reveal yet another limiting approximation. Similar to Figs 2 and 3, the boundary is reached just before τ ≈ 2 (top). Bottom left: the final parameter space velocities (v1 ∼ log kf, v2 ∼ log kr v3 ∼ log E0, and v4 ∼ log S0) indicate that the limit corresponds to two parameters becoming infinite and a third becoming zero. Bottom right: the smallest FIM eigenvalue becomes zero at the manifold boundary.