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. 2016 May 17;12(5):e1004915. doi: 10.1371/journal.pcbi.1004915

Fig 10. EGFR network condensation for each choice of QoI.

Fig 10

By coarsening the QoIs, MBAM gives models with fewer identifiable parameters as in Fig 9 that condense the full network into an effective, minimal, topology. Top, left: The full topology of the original model. Top, right: The reduced topology that can explain the time series of all biochemical species. Bottom, left: The minimal topology for explaining the data in reference [7]. Bottom, center: The minimal topology for explaining only the input/output relations of the network. Double lines represent algebraic relationships between nodes. Bottom, right: Considering only the adaptive response to EGF stimulus recovers the minimal negative feedback motif in Fig 6.