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. 2016 May 17;12(5):e1004915. doi: 10.1371/journal.pcbi.1004915

Fig 11. Parameter sensitivities in a minimal EGFR Signaling model.

Fig 11

A four parameter EGFR model can explain the adaptive behavior of ERK in response to EGF stimulus (black line within the red bands, compare Figs 7 and 8). Varying any of the four remaining parameters move the behavior of the model outside the allowed region (dashed lines). These parameters span the same four phenomenological degrees of freedom as in Figs 5, 7 and 8.