Fig 1. Multiscale spatio-temporal model checking workflow.

The first step (1) in the workflow is using biological observations and/or information from the literature to construct the multilevel computational model of the biological system considered. Next (2) the model is simulated to produce time series data in which spatial entities from multiple scales are automatically detected and analysed using a multiscale spatio-temporal analysis module. Then (3) the specification against which the model is verified is translated from natural language to a formal multiscale spatio-temporal language called PBLMSTL. Finally (4) using the model checker Mule the model is automatically verified relative to the given PBLMSTL specification considering the processed time series data representing the modelled system behaviour. If the model is declared incorrect relative to the given specification then it is updated and the steps (2) and (4) are repeated.