Table 1. Comparison of the presence of fibrinogen (in %) in plasma in presence of native SK and PEG-SK variantsa.
| Time points | Concentration (nM) | nSK (%) | SK1-383C-PEG20 (%) | SK1-383N-PEG20 (%) |
|---|---|---|---|---|
| 15 min | 25.0 | 65.9 | 81.2 | 93.0 |
| 30 min | 25.0 | 44.8 | 66.7 | 83.8 |
a25 nM concentration of nSK/truncated PEGylated derivatives was incubated in plasma and appropriate amount of aliquots were removed after every 15 min to determine the amount of fibrinogen (see Materials and Methods for details). Average values (mean of three determinations) of variants are shown in the table.