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. 2016 May 18;11(5):e0155802. doi: 10.1371/journal.pone.0155802

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© 2016 Fongang, Kudlicki

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — A GC rich regulatory motif denoted as A1 in the text was found to be overrepresented in the promoter of nearly ¾ of reported cyclic genes during chicken somitogenesis. The average position of the motif is around 300 bps upstream of the transcription start site for mouse genes. When tested for enrichment in the database of experimentally validated TFBSs, it appears this regulatory motif may contain the binding sites of several couple of TFs acting cooperatively to regulate the expression of corresponding genes. The first and second possibilities (panels A and B) is the TF E2F1 binding upstream of EGR1 and ZNF263 respectively and the others possibilities (panels C and D) involve the TF PLAG1 binding upstream of RREB1 and EGR2.