Skip to main content
. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Cell Stem Cell. 2016 May 5;18(5):573–586. doi: 10.1016/j.stem.2016.04.013

Figure 3.

Figure 3

Strategy to generate isogenic iPSCs that differ at multiple risk alleles. GWAS have identified genomic loci that may slightly increase the risk of developing a sporadic disease. The key challenge of using patient-derived iPSCs to get mechanistic insight into risk alleles is to create meaningful control cells. CRISPR/Cas9 mediated gene editing would allow to exchange risk (red squares) and protective (green squares) alleles and to generate appropriate control cells that differ exclusively at the risk loci under study.