Table 5.

Percentages of each dose levels recommended as MTD in different scenarios.^a

Scenario	Dose levelb	Probability of DLTs for the dose	ANETS for the dose	Percentages (%) the dose chosen as MTD
				EIDc	IDd	Standardd	CRMd
Target-Scenario	1	0.08	0.34	12	16	45	10
	2	0.24	0.43	33	34	33	34
	3	0.33	0.48	35	34	17	35
	4	0.44	0.54	17	14	4	19
	5	0.56	0.61	3	2	0.4	2
	6	0.76	0.71	0.1	0	0	0
Under-Toxic-Scenario	1	0.08	0.27	37	16	45	10
	2	0.24	0.36	15	34	33	34
	3	0.33	0.41	30	34	17	35
	4	0.44	0.48	36	14	4	19
	5	0.56	0.56	15	2	0.4	2
	6	0.76	0.67	1	0	0	0
Over-Toxic-Scenario	1	0.08	0.41	36	16	45	10
	2	0.24	0.49	40	34	33	34
	3	0.33	0.53	20	34	17	35
	4	0.44	0.59	4	14	4	19
	5	0.56	0.65	0.3	2	0.4	2
	6	0.76	0.75	0	0	0	0

^aDLT: dose limiting toxicity. MTD: maximum tolerated dose. EID: extended isotonic design. ID: isotonic design. ANETS: averaged normalized equivalent toxicity score.

^bThe dose level in bold and with underline is the true MTD.

^cDesigns treating toxicity response as quasi-continuous variable is targeted with TNETS≤0.476.

^dDesigns treating toxicity response as binary variable is targeted with TTL≤0.33.