Table 6.

Summary of dose level and toxicity of patients in A09712.^a

Dose level	Treatment	Toxicities
		Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
1	1.7 mg/kg/dose M–F*3w	2G2 3G1	None	1G2 2G1	1G2 4G1
2	1.7 mg/kg/dose MWF*6w	1G1	None	2G1	2G1
3	1.7 mg/kg/dose M–F*6w	3G2 5G1	1G2 1G1	1G1	None
4	1.9 mg/kg/dose M–F*6w	None	1G1	1G3DLT 2G3 5G2 1G1	1G2 2G1	4G1	1G2 3G1
5	3.4 mg/kg/dose M–F*6w	1G2 1G1	2G1	2G1	None
6*	4.4 mg/kg/dose M–F*6w	1G2 1G1	2G2 1G1	2G2 2G1	1G3DLT 2G3 2G2 2G1	2G2 2G1	1G3 3G2 6G1
7	5.5 mg/kg/dose M–F*6w	1G2	1G2 1G1	2G2 2G1	1G3DLT 1G2 2G1	1G3DLT 1G3 2G2 1G1	2G2 6G1
8	7.1 mg/kg/dose M–F*6w	2G2 1G1	2G2 1G1	2G2 2G1	1G3DLT 1G3 2G2 3G1	1G3DLT 1G3 4G2 5G1
9	9.2 mg/kg/dose M–F*6w	1G3DLT 2G3 4G2 2G1	1G3DLT 1G2 1G1

nGm: n grade m non-DLT toxicities. nGmDLT: n grade m DLT toxicities.

^*Recommended maximum tolerated dose (MTD) by original Standard 3+3 design with dose de-escalation.

^aM: Monday. F: Friday. w: week. DLT: dose limiting toxicity.