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. Author manuscript; available in PMC: 2016 Dec 17.
Published in final edited form as: Cell. 2015 Dec 17;163(7):1585–1595. doi: 10.1016/j.cell.2015.11.055

Figure 6. Schema showing use of DMB to inhibit gut microbial trimethylamine production for the treatment of atherosclerosis.

Figure 6

DMB (3,3-dimethyl-1-butanol) is a structural analogue of choline, and an inhibitor of microbial TMA production (a choline TMA lyase inhibitor). Provision of DMB in the drinking water of atherosclerosis prone Apoe−/− mice inhibits choline diet dependent enhancement in TMAO, endogenous macrophage foam cell formation, and atherosclerosis development.