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Complete activity and selectivity profile of selected subtype 11 compounds.
| Compd | RNase H IC50a (µM) |
RT Pol IC50 (µM) (SIb) |
INST IC50 (µM) (SIb) |
CC50 (µM) |
|---|---|---|---|---|
| 11b | 0.40 | 5.7 (14) | 93 (230) | >25 |
| 11i | 0.15 | 7.3 (49) | >100 (>670) | >25 |
| 11j | 0.20 | 6.3 (32) | >100 (>500) | >25 |
| 11o | 0.20 | 6.6 (33) | >100 (>500) | >25 |
Data with HTS-1 as substrate.
Selectivity index, defined as IC50 RT pol or IN / IC50 RNase H.
