Table 3.
Causative agents of bloodstream infection in patients with solid tumors compared with patients with hematologic malignancies.
| Marin et al. 2014 [19] | Schelenz et al. 2013 [18] | |||||
|---|---|---|---|---|---|---|
| Population studied | Only neutropenic patients were inlcuded |
Neutropenic and non-neutropenic patients |
||||
| Causative agents | Hematological malignancy N = 493 (%) | Solid tumor N = 86 (%) | p | Hematological malignancy N = 473 (%) | Solid tumor N = 441 (%) | p |
| Gram-positive bacteria | 206 (41.8) | 27 (31.4) | 0.075 | 302 (62) | 258 (56) | 0.03 |
| Coagulase-negative staphylococci | 94 (45.6) | 6 (22.2) | 0.005 | 168 (35.5) | 125 (28.3) | — |
| Staphylococcus aureus including MRSA | 31 (6.3) | 6 (7) | 0.80 | 37 (7.8) | 44 (10) | — |
| Viridans group streptococci | 39 (18.9) | 6 (22.2) | 1.0 | 54 (11.4) | 19 (4.3) | — |
| Enterococcus spp. | 44 (21.3) | 2 (7.4) | 0.032 | 20 (4.2) | 20 (4.5) | — |
| Streptococcus pneumoniae | 12 (5.8) | 3 (11.1) | 0.47 | 7 (1.5) | 12 (2.7) | — |
| β.hemolytic streptococci | — | — | — | 7 (1.5) | 13 (2.9) | — |
| Bacillus spp | — | — | — | 5 (1.1) | 8 (1.8) | — |
| Other Gram-positive bacteria | — | — | — | 3 (0.9) | 5 (1.6) | — |
| Gram-negative bacteria | 234 (47.5) | 52 (60.5) | 0.027 | 163 (33) | 189 (41) | 0.03 |
| Escherichia coli | 121 (51.7) | 19 (36.5) | 0.68 | 40 (8.5) | 61 (13.8) | — |
| Pseudomonas aeruginosa | 52 (22.2) | 22 (42.3) | <0.001 | 33 (7.0) | 23 (5.2) | — |
| Klebsiella spp. | 54 (23) | 12 (23 ) | 0.46 | 16 (3.4) | 27 (6.1) | — |
| Enterobacter spp | 20 (8.5) | 1 (1.92) | 0.34 | 22 (4.7) | 14 (3.2) | — |
| Serratia spp. | — | — | — | 2 (0.4) | 4 (0.9) | — |
| Proteus spp | — | — | — | 3 (0.6) | 4 (0.9) | — |
| MDR Gram-negative bacillia | 36 (15.4) | 2 (3.84) | 0.1 | — | — | — |
| ESBL-producing Enterobacteriaceae | 21 (58.3) | 2 (2.4) | 0.55 | — | — | — |
| Stenotrophomonas maltophilia | 9 (25) | 0 (0) | 0.36 | 21 (4.4) | 32 (7.3) | — |
| AmpC-producing Enterobacteriaceae | 3 (8.3) | 0 (0) | 1.00 | — | — | — |
| MDR Pseudomonas aeruginosa | 2 (3.33) | 0 (0) | 1.00 | — | — | — |
| Acinetobacter baumannii | 1 (2.7) | 0 (0) | 1.00 | 7 (1.5) | 7 (1.6) | — |
| Other Gram-negative bacteria | — | — | — | 5 (3) | 3 (1.5) | — |
| Ciprofloxacin-resistant GNB | — | — | — | (22) | (5) | 0.058 |
| Anaerobes | 11 (2.2) | 3 (3.5) | 0.44 | 6 (1.3) | 8 (1.8) | — |
| Polymicrobial | 51 (10.3) | 8 (9.3) | 1.00 | — | — | — |
| Fungi | 11 (2.2) | 0 (0) | 0.36 | 5 | 13 | — |
MDR: Multidrug resistant
ESBL.Extended.spectrum β-lactamase