Table 4.
Empirical antibiotic therapy and outcomes of patients with solid tumors and bloodstream infection. Empirical antibiotic therapy and outcomes of neutropenic patients with solid tumors compared with patients with hematologic malignancies.
| Characteristic | Marín et al. 2014 [26] | Anatoliotaki et al. 2004 [27] | Marín et al. 2014 [19] |
||
|---|---|---|---|---|---|
| Population studied | Neutropenic and non-neutropenic patients with solid tumors N = 528 (%) | Neutropenic and non-neutropenic patients with solid tumors N = 157 (%) | Neutropenic patients with hematological malignancies N = 493 (%) | Neutropenic patients with solid tumors N = 86 (%) | p |
| Empirical antibiotic therapy | 497 (94) | — | 478 (97) | 86 (100) | 0.144 |
| Monotherapy | |||||
| Carbapenem | 69 (13) | — | 43 (8.7) | 4 (4.7) | 0.209 |
| Glycopeptide | — | — | 34 (7.1) | 1 (1.2) | 0.029 |
| Oxymino.β.lactam | 122 (23) | — | 26 (5.4) | 1 (1.2) | 0.062 |
| β.lactam + β.lactamase inhibitor | 296 (56) | — | 20 (4.2) | 14 (16.3) | <0.001 |
| Quinolone | 64 (12) | ||||
| Combination therapy | |||||
| Cephalosporin + aminoglycoside | 74 (14) | — | 220 (46) | 46 (53.5) | 0.2 |
| Amoxicillin clavulanate + ciprofloxacin | 0 (0) | 5 (5.8) | <0.001 | ||
| Other | — | — | 135 (28.2) | 15 (17.4) | 0.766 |
| Inadequate initial empirical antibiotic therapy | 123 (23) | 46 (29.2) | 120 (24.4) | 11 (12.8) | 0.017 |
| Growing factors | — | — | 129 (26.7) | 32 (38.1) | 0.036 |
| Shock at presentation | 69 (13) | 30 (19) | 49 (10) | 25 (29) | <0.001 |
| Intensive care unit admission | 9 (2) | — | 55 (11.2) | 2 (2.3) | 0.009 |
| Invasive mechanical ventilation | 6 (1) | — | 29 (52.7) | 0 (0) | 0.014 |
| Overall case-fatality rate (30 days) | 163 (32) | 32 (20) | 59 (12.1) | 32 (37.6) | <0.001 |
| Early case-fatality rate (48 hours) | 36 (7) | — | 19 (3.9) | 11 (12.8) | 0.02 |