TABLE 1.
MyomiR: muscle-specific microRNA.
MyomiR | Host Gene | Expression Pattern | Knockout Phenotype | Study |
---|---|---|---|---|
MiR-1-1 | Mib1 | Heart, skeletal muscle | No knockout | — |
MiR-1-2 | Intergenic | Heart, skeletal muscle | 50% lethal, cardiac defect | Zhao et al., 2007 (38) |
MiR-133a-1 | Mib1 | Heart, skeletal muscle | No overt phenotype | Liu et al., 2008 (22) |
MiR-133a-2 | Intergenic | Heart, skeletal muscle | No overt phenotype | Liu et al., 2008 (22) |
MiR-206 | Intergenic | Skeletal muscle (Type I) | No overt phenotype | Williams et al., 2009 (37) |
MiR-208a | Myh6 | Heart | Blunted stress response | van Rooij et al., 2007 (36) |
Conduction defects | Callis et al., 2009 (5) | |||
MiR | Myh7 | Heart (low), skeletal muscle (Type I) | No overt phenotype | van Rooij et al., 2009 (35) |
MiR | Ank1 | Heart, skeletal muscle | No knockout | — |
MiR | Myh7b/14 | Heart, skeletal muscle (Type I) | No overt phenotype | van Rooij et al., 2009 (35) |