TABLE 2.
MyomiR expression in response to changes in contractile activity.
| MyomiR | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Modality | Duration | Species | Muscle | 1 | 133a | 206 | 208b | 486 | 499 | Study |
| Resistance exercise | ||||||||||
| Mechanical overload | 14 d | Mouse | Plantaris | ↓50% | ↓50% | No Δ | — | — | — | McCarthy, 2007 (24) |
| Leg extension + essential amino acids | 8 × 10 | Human | Vastus lateralis | ↓38% | No Δ | No Δ | — | — | — | Drummond et al., 2008 (7) |
| Unloading | ||||||||||
| Immobilization | 5 d | Mouse | Gastrocnemius | ↓22% | No Δ | ↓13% | Low | No Δ | Low | Aoi et al., 2010 (2) |
| Spaceflight | 12 d | Mouse | Gastrocnemius | No Δ | No Δ | ↓50% | — | — | — | Allen et al., 2009 (1) |
| Hind limb unloading | 7 and 28 d | Rat | Soleus | No Δ | No Δ | No $ | ?60% | — | ↓40% | McCarthy et al., 2009 (26) |
| Endurance exercise | ||||||||||
| Treadmill running | 90 min | Mouse | Quadriceps | 40% | No Δ | — | — | — | — | Safdar et al., 2009 (30) |
| Cycle ergometer | 60 min | Human | Vastus lateralis | ↑30% | ↑37% | No Δ | — | — | — | Nielsen et al., 2010 (28) |
| Treadmill running | 4 wk | Mouse | Gastrocnemius | ↑71% | No Δ | ↑24% | Low | ↑24% | Low | Aoi et al., 2010 (2) |
| Cycle ergometer | 12 wk | Human | Vastus lateralis | ↓32% | ↓23% | ↓19% | — | — | — | Nielsen et al., 2010 (28) |
Down arrow (↓), decreased expression; em-dash (—), expression not measured; low, low expression; myomiR, muscle-specific microRNA; no Δ, no change in expression; up arrow (↑), increased expression.