Renal cell carcinoma (RCC) and Angiogenesis. The factors supporting micrometastatic disease, and early progression may be independent of the angiogenesis that high tumor burden metastatic disease requires for support. VEGF, vascular endothelial growth factor; PDGF, platelet-derived growth factor; VEGFR, vascular endothelial growth factor receptor; PDGFR, platelet-derived growth factor receptor.