Table 3.

Short-term odds ratios for a serious fall injury associated with initiation, adding a new drug class, and antihypertensive medication titration.

	Overall (N=90,127 serious fall injuries)			Prior hypertension diagnosis* (N=90,127 serious fall injuries)			No recent hospitalization† (N=60,211 serious fall injuries)
	Case period N(%‡)	Control periods N(%§)	OR (95% CI)	Case period N(%‡)	Control periods N(%§)	OR (95% CI)	Case period N(%‡)	Control periods N(%§)	OR (95% CI)
Initiation	272 (0.30)	1,201 (0.22)	1.36 (1.19, 1.55)	159 (0.18)	701 (0.13)	1.36 (1.15, 1.62)	146 (0.24)	635 (0.18)	1.38 (1.15, 1.65)
Addition of new class	1,508 (1.67)	7,820 (1.45)	1.16 (1.10, 1.23)	1,276 (1.42)	6,664 (1.23)	1.15 (1.09, 1.23)	687 (1.14)	3,450 (0.95)	1.20 (1.10, 1.30)
Titration	3,113 (3.45)	16,714 (3.09)	1.13 (1.08, 1.18)	2,696 (2.99)	14,542 (2.69)	1.12 (1.08, 1.17)	1,432 (2.38)	7,662 (2.12)	1.13 (1.07, 1.20)

Initiation, adding a new drug class, or antihypertensive medication titration during the case period (within 15 days prior to fall) was compared with initiation of antihypertensive medication during six control periods (30–44, 60–74, 90–104, 120–134, 150–164, and 180–194 days prior to the fall).

^*For the prior hypertension diagnosis, definitions of initiation, addition of a new antihypertensive medication class, and antihypertensive medication titration additionally required having one or more diagnoses of hypertension (International Classification of Diseases, 9th Revision [ICD-9] diagnoses of 401.xx) in the 365 days prior to the case or control period.

^†Beneficiaries who were hospitalized within 365 days prior to their serious fall injury were excluded.

^‡Calculated as 100 times (number of serious fall injuries in case period divided by total number of serious fall injuries).

^§Calculated as 100 times (total number of serious fall injuries across the control periods divided by the product of six control periods times total number of serious fall injuries)