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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Prog Neurobiol. 2015 Nov 18;157:273–291. doi: 10.1016/j.pneurobio.2015.10.005

Figure 3.

Figure 3

Methylene blue feeding improved water-maze and bridge walking performance in 5 X FAD mice. Wild type and 5 X FAD female mice were switched to diets containing MB or vehicle at the age of 8 weeks and continually fed for 8 months. At the age of 10 months, the mice were subjected to batteries of behavioral testing of water-maze and bridge walking as described previously (Shetty et al., 2014). MB diet group had significantly reduced average latency to fall in the bridge walking test as compared to control diet group (A). In water-maze test, MB feeding significantly improved learning index (B). All mice were sacrificed and the effect of MB on brain Aβ plaques were determined. MB feeding decreases Aβ plaque evidenced by 6E10 immunohistochemistry (C) and Western blot analysis (D). # p<0.05 vs Control AD. * p<0.05 vs Control wild-type.