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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Prog Neurobiol. 2015 Nov 18;157:273–291. doi: 10.1016/j.pneurobio.2015.10.005

Figure 4.

Figure 4

Reprograming energetic metabolism for the treatment of neurodegenerative diseases and brain tumor. Metabolic reprograming may serve as a common mechanistic foundation for neurodegenerative diseases and cancers. Accordingly, targeting energy metabolism may provide a one stone two birds strategy for the treatment both neurodegenerative diseases and cancers. While enforcing brain bioenergetics may enhance brain function hence slow down or prevent the progression of neurodegenerative diseases, switching cancer metabolic phenotype from biosynthetic back to bioenergetic might exhaust building brick for cancer biomass, thus, inhibit cancers proliferation.