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. 2016 Mar 1;30(6):2187–2197. doi: 10.1096/fj.201600223R

Figure 4.

Figure 4.

PDSinh-A01 selectivity studies. A) Isc in IL-13-treated HBE cells in response to agonists and inhibitors that target key ion transport processes: 20 μM amiloride; 20 μM forskolin; 10 μM CFTRinh-172; 100 mM ATP. Experiments were done in absence (left, top) and presence (left, bottom) of PDSinh-A01 (25 μM, 30 min pretreatment). (right) Summary of ΔIsc data (means ± sem, n = 3, differences not significant). B) PDSinh-A01 (25 μM, 30 min) does not inhibit thiocyanate transport by human SLC26A3 as assayed by YFP fluorescence responses after application of 70 mM SCN− gradient. Fluorescence responses (left) and data summary (right). Data shown as means ± sem (n = 17–25 cells). P value differences are not significant.