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Pharmacological activation of S1P1 reverses the increased vascular permeability in Apom−/− mice. WT and Apom−/− mice (n = 6) were treated with 10 mg/kg W146 (S1P1 antagonist) or SEW2871 (S1P1 agonist) or saline 6.5 h before injection of Evans blue for assessment of vascular permeability in lung tissue. *P ≤ 0.05, *P ≤ 0.01, ***P ≤ 0.001, 1-way ANOVA with Tukey’s post hoc test.
