Table 1.
Assay of the susceptibility of planktonic cells to antibiotics (mg/L).
| Target (type) | antibiotic category | compound | MIC in LB | MIC change (fold) | MIC in MOPS | MIC fold (fold) | References | ||
|---|---|---|---|---|---|---|---|---|---|
| PCN033 | Δppk | PCN033 | Δppk | ||||||
| Cell wall biosynthesis(A) | β-lactams | cefotaxime | 2 | 1 | 2 | 16 | 4 | 4 | Bush, 2012 |
| ceftazidime | 256 | 256 | 1 | 512 | 512 | 1 | |||
| ampicillin | >512 | >512 | 1 | >512 | >512 | 1 | |||
| cefazolin | >512 | >512 | 1 | >512 | >512 | 1 | |||
| tazobactam | >512 | >512 | 1 | >512 | 256 | >2 | |||
| ticarcillin | >512 | >512 | 1 | >512 | >512 | 1 | |||
| Glycopeptide | vancomycin | >512 | >512 | 1 | 128 | 64 | 2 | ||
| Protein biosynthesis (B) | Aminoglycosides | gentamicin | >512 | >512 | 1 | 256 | 32 | 8 | Davis, 1987 |
| gentamicin sulfate | >512 | >512 | 1 | 256 | 64 | 4 | |||
| amikacin | >512 | >512 | 1 | >512 | 64 | ≥4 | |||
| Macrolide | Erythromycin | 512 | 512 | 1 | 512 | 128 | 4 | Brisson-Noël et al., 1988 | |
| Nucleotide metabolism (C) | Quinolones | norfloxacin | >512 | 512 | >1 | 512 | 512 | 1 | Aldred et al., 2014 |
| levofloxacin | 128 | 64 | 2 | 64 | 16 | 4 | |||
| Sulfonamides | Trimethoprim | 128 | 128 | 1 | 256 | 128 | 2 | Pérez-Trallero and Iglesias, 2003 | |
| sulfadiazine | >512 | >512 | >1 | >512 | >512 | 1 | |||
| Nitrofurans | macrodantin | 512 | 256 | 2 | 128 | 128 | 1 | Hof, 1988 | |
| Membrane (D) | Lipopeptde | polymyxin B | 0.5 | ≤ 0.25 | ≥2 | 2 | 1 | 2 | Grau-Campistany et al., 2015 |