Table 2.
Assay of the susceptibility of biofilm-grown cells to antibiotics (mg/L).
| Target (type) | antibiotic category | compound | MIC for biofilm | MIC change (fold) | |
|---|---|---|---|---|---|
| PCN033 | Δppk | ||||
| Cell wall biosynthesis (A) | β-lactams | cefotaxime | 128 | 256 | 0.5 |
| ceftazidime | 512 | 512 | 1 | ||
| ampicillin | >512 | >512 | 1 | ||
| cefazolin | >512 | >512 | 1 | ||
| tazobactam | 512 | >512 | ≤ 0.5 | ||
| ticarcillin | >512 | >512 | 1 | ||
| Protein biosynthesis (B) | Aminoglycosides | gentamicin | 512 | 512 | 1 |
| gentamicin sulfate | 512 | 256 | 2 | ||
| amikacin | 512 | 512 | 1 | ||
| Macrolide | erythromycin | 512 | 512 | 1 | |
| Quinolones | norfloxacin | 512 | 512 | 1 | |
| levofloxacin | 32 | 32 | 1 | ||
| Nucleotide metabolism (C) | Sulfonamides | Trimethoprim | 512 | 512 | 1 |
| sulfadiazine | >512 | >512 | 1 | ||
| Nitrofurans | macrodantin | 512 | 512 | 1 | |
| Membrane (D) | Lipopeptde | polymyxin B | 4 | 4 | 1 |