Table 1.
Volumes of brain structures from normal (n=19) and humanized (n=7) mice.
| Region | Structure | Normal Mean ± SD (mm3) (n=19) |
Humanized Mean ± SD (mm3) (n=7) |
|---|---|---|---|
| CH: Cerebrum | |||
| Isocortex: Isocortex | Isocortex: Isocortex | 116.64±4.49 | 97.46±6.32 |
| OLF: Olfactory areas | MOBgl: Main olfactory bulb, glomerular layer | 15.44±1.37 | 12.11±1.06 |
| MOBgr: Main olfactory bulb, granule layer | 3.36±0.35 | 2.60±0.26 | |
| AOB: Accessory olfactory bulb | 0.79±0.08 | 0.66±0.05 | |
| AON: Anterior olfactory nucleus | 4.77±0.28 | 4.13±0.19 | |
| PIR: Piriform area | 12.56±0.48 | 10.43±0.65 | |
| HPF: Hippocampal formation | CA1_CA2_SUB: Field CA1+Field CA2+Subiculum | 17.32±0.55 | 13.68±1.38 |
| CA3: field CA3 of hippocampus | 7.87±0.23 | 6.51±0.59 | |
| DG-mo: Dentate gyrus_molecular layer | 3.35±0.13 | 2.75±0.31 | |
| DG-(po+sg): Dentate gyrus_(polymorph layer+granular layer) | 3.06±0.13 | 2.54±0.29 | |
| STR: Striatum | CP: Caudoputamen | 23.30±0.84 | 19.95±1.24 |
| STRv: Striatum ventral region | 12.06±0.52 | 10.00±0.61 | |
| LSX: Lateral septal complex | 4.41±0.16 | 3.99±0.17 | |
| PAL: Pallidum | PALc: Pallidium, caudal region | 2.44±0.12 | 2.15±0.11 |
| GP: Globus pallidus | 3.15±0.12 | 2.74±0.16 | |
| MS: Medial septal nucleus | 0.35±0.02 | 0.32±0.01 | |
| AMY: Amygdala | AMY: Amygdala | 18.1±0.72 | 14.55±0.92 |
| FB: Fiber tracts | |||
| cc: corpus callosum | 11.85±0.58 | 9.84±0.76 | |
| opt: optic tract | 0.85±0.04 | 0.72±0.05 | |
| ac: anterior commissure | 0.82±0.03 | 0.71±0.04 | |
| RFB: Rest of fiber tracts | 9.13±0.3 | 7.9±0.5 | |
| BS: Brain stem | |||
| TH: Thalamus | 19.67±0.58 | 17.37±1.12 | |
| EPI: Epithalamus | 0.87±0.04 | 0.79±0.06 | |
| HY: Hypothalamus | 19.02±0.69 | 16.51±0.57 | |
| IC: Inferior colliculus | 6.50±0.28 | 5.58±0.36 | |
| PAG: Periaqueductal gray | 7.59±0.24 | 6.71±0.32 | |
| PRT: Pretectal region | 2.59±0.08 | 2.26±0.21 | |
| SN: Substantia nigra | 2.63±0.10 | 2.36±0.12 | |
| RMB: Rest of midbrain | 23.95±0.56 | 20.82±1.36 | |
| P: Pons | 19.68±0.88 | 17.46±0.85 | |
| MY: Medulla | 52.51±3.12 | 43.55±2.62 | |
| CB: Cerebellum | |||
| CBXmo: Cerebellar cortex, molecular layer | 44.35±1.57 | 36.06±3.19 | |
| CBXgr: Cerebellar cortex, granular layer | 11.65±0.42 | 9.24±0.92 | |
| CBwm: Cerebellar white matter | 14.20±0.48 | 11.46±1.18 | |
| FN: Fastigial nucleus | 0.64±0.04 | 0.54±0.06 | |
| IP: Interpose nucleus | 1.07±0.05 | 0.88±0.12 | |
| DN: Dentate nucleus | 0.72±0.05 | 0.58±0.07 | |
| VS: Ventricular system | |||
| VL: Lateral ventricles | 2.47±0.09 | 2.16±0.16 | |
| V3: Third ventricle* | 0.52±0.03 | 0.47±0.04 | |
| AQ: Cerebral aqueduct* | 0.123±0.01 | 0.121±0.01 | |
| V4: Fourth ventricle | 1.21±0.07 | 1.00±0.09 | |
| Brain volume | 503.63±13.05 | 421.66±25.62 |
‘*’ denotes NOT significant (p>0.01) volume differences