Table 1.
Evaluation of interaction resulting from the combination of the substances tested by determining the FICindex using the checkerboard technique.
| Strain | MIC (µg/mL) | MIC in combination (µg/mL) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EO | La | Gb | FLCc | FLC | EO | FICd
index |
FLC | L | FIC index |
FLC | G | FIC index |
L | G | FIC index |
|
| C. neoformans | 1250 | 790 | 76 | 31.25 | 4.14 | 625 | 0.633 (I)e |
8.054 | 197 | 0.5077 (I) |
4.14 | 19 | 0.3826 (S) |
111 | 19 | 0.3905 (S) |
| C. albicans resistant | 1250 | 1580 | 152 | 500 | 1.01 | 156 | 0.127 (S)f |
2.02 | 197 | 0.134 (S) |
1.04 | 38 | 0.252 (S) |
397 | 4.8 | 0.284 (S) |
| C. albicans sensitive | 1250 | 790 | 152 | 0.975 | 0.259 | 312 | 0.51 (I) |
0.065 | 395 | 0.57 (I) |
0.259 | 38 | 0.51 (I) |
105 | 38 | 0.38 (S) |
aL: linalool; bG: geraniol; cFLC: fluconazole; dFIC index: fractional inhibitory concentration index; eI: indifferent; fS: synergist.