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. 2016 May 18;36(20):5448–5461. doi: 10.1523/JNEUROSCI.4247-15.2016

Figure 1.

Figure 1.

Loss of Bcl-xL in the dorsal telencephalon results in microcephaly. A, tdTomato+/Cre− (rosa26reporter–tdTomato; no Cre control) and tdTomato+/Cre+ (Emx1–Cre; rosa26reporter–tdTomato) brains at E12.5 stained with RFP show the recombination pattern of the Emx1–Cre line. Scale bar, 100 μm. B, Wild-type and Bcl-xLEmx1–Cre mouse cortices stained with Bcl-xL at P1. Samples were counterstained with hematoxylin. Scale bar, 50 μm. C, Wild-type and Bcl-xLEmx1–Cre mice at P1. Images of brains (D) and brain weights of P1 wild-type and Bcl-xLEmx1–Cre mice (E). F, Wild-type and Bcl-xLEmx1–Cre mice at P25. Images of brains (G) and brain weights of P25 wild-type and Bcl-xLEmx1–Cre mice (H). Data shown are means ± SEM for each group. **p < 0.01; n.s., not significant.