Table 2.
Sample Characteristics by ODX Use and Lymph Node Status
| Characteristic | Full Sample | Node Positive | Node Negative | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No ODX | ODX | P | No ODX | ODX | P | No ODX | ODX | P | |
| n | 900 | 568 | 302 | 81 | 598 | 487 | |||
| Weighted n | 2,734 | 1,953 | 734 | 313 | 2,001 | 1640 | |||
| Tumor | |||||||||
| Size, cm | .04 | .18 | < .001 | ||||||
| < 2 | 74 | 73.6 | 49.4 | 61.1 | 83.1 | 75.9 | |||
| 2-5 | 22.9 | 25.8 | 48.7 | 38.1 | 13.5 | 23.4 | |||
| > 5 | 3 | 0.7 | 2 | 0.8 | 3.4 | 0.7 | |||
| Grade | .003 | .03 | < .001 | ||||||
| 1 | 40.7 | 31 | 26.6 | 28.4 | 45.9 | 31.5 | |||
| 2 | 41.3 | 53.1 | 43.2 | 58.4 | 40.6 | 52 | |||
| 3 | 18 | 16 | 30.2 | 13.2 | 13.5 | 16.5 | |||
| PR positive | 86.5 | 91.1 | .03 | 89.7 | 90.4 | .86 | 85.3 | 91.2 | .01 |
| Treatment | |||||||||
| Start ET | 87.1 | 94.1 | <.001 | 90.6 | 97 | .12 | 85.9 | 93.6 | < .001 |
| Start adjuvant CT | 30.7 | 26.7 | .18 | 70.4 | 30.9 | < .001 | 16.1 | 25.9 | < .001 |
| Radiation therapy | 69.4 | 66.4 | .38 | 77.2 | 61.1 | .01 | 66.5 | 67.4 | .82 |
| Lumpectomy* | 38.7 | 35.4 | .43 | 55.8 | 38.6 | .01 | 32.4 | 34.8 | .56 |
| Clinical | |||||||||
| Age at diagnosis, years | 57.6 (10.9) | 56.9 (9.9) | .28 | 54.0 (12.0) | 58.3 (8.1) | .004 | 58.9 (10.1) | 56.6 (10.3) | .002 |
| Diagnosis year | > .99 | .08 | .41 | ||||||
| 2008 | 10.9 | 11.5 | 18.2 | 6.7 | 8.2 | 12.5 | |||
| 2009 | 19 | 19.8 | 17.6 | 16.1 | 19.5 | 20.5 | |||
| 2010 | 24.6 | 23.4 | 20.8 | 17.6 | 26 | 24.5 | |||
| 2011 | 24.6 | 24.3 | 25.7 | 28.5 | 24.1 | 23.5 | |||
| 2012 or 2013 | 20.9 | 21.0 | 17.2 | 29.8 | 21.9 | 18.9 | |||
| Comorbidities | |||||||||
| Diabetes | 15.5 | 10.6 | .03 | 15.7 | 10.6 | .39 | 15.4 | 10.6 | .06 |
| COPD | 4.9 | 1.8 | .01 | 5.3 | 0 | .08 | 4.8 | 2.1 | .05 |
| Obesity | 13 | 12.6 | .86 | 14.3 | 6.5 | .12 | 12.5 | 13.8 | .59 |
| Heart disease | 8.9 | 3.9 | .005 | 8.5 | 4.8 | .4 | 9 | 3.7 | .008 |
| Hypertension | 45.3 | 40.8 | .19 | 41.8 | 49.3 | .28 | 46.7 | 39.2 | .07 |
| Socioeconomic | |||||||||
| Family income, $ | < .001 | .002 | .006 | ||||||
| < 15,000 | 12.2 | 7.2 | 15.9 | 6.1 | 10.9 | 7.4 | |||
| 15,000-30,000 | 15.6 | 12.9 | 14.2 | 12.2 | 16.1 | 13 | |||
| 30,000-50,000 | 17.4 | 17.6 | 21 | 9.4 | 16 | 19.2 | |||
| > 50,000 | 46.2 | 58.1 | 43.2 | 70.7 | 47.3 | 55.7 | |||
| Not reported | 8.6 | 4.1 | 5.7 | 1.7 | 9.7 | 4.6 | |||
| Insurance | |||||||||
| Private | 74.6 | 79.1 | .13 | 72.8 | 79 | .39 | 75.3 | 79.1 | .26 |
| Medicaid | 10.3 | 6.7 | .03 | 11.9 | 9.1 | .55 | 9.7 | 6.3 | .04 |
| Medicare | 37.3 | 33.5 | .24 | 29 | 30.5 | .82 | 40.3 | 34.1 | .09 |
| Uninsured | 4.7 | 3 | .06 | 6.1 | 2.7 | .08 | 4.2 | 3.1 | .3 |
| Married | 62.7 | 70 | .02 | 62.1 | 73.6 | .06 | 62.8 | 69.3 | .06 |
| Employment Status | .11 | .35 | .009 | ||||||
| Unemployed | 57.4 | 50.9 | 53.1 | 53 | 59 | 50.5 | |||
| Employed | 41.7 | 48.5 | 46.1 | 43.8 | 40 | 49.3 | |||
| Not reported | 0.9 | 0.7 | 0.8 | 3.2 | 1 | 0.2 | |||
| Education | .07 | .56 | .09 | ||||||
| HS | 51 | 49.1 | 41.8 | 47.9 | 54.4 | 49.3 | |||
| College or higher | 40.3 | 45.4 | 46.1 | 44.1 | 38.2 | 45.6 | |||
| Less than HS | 8.7 | 5.6 | 12.2 | 8 | 7.4 | 5.1 | |||
NOTE. Data are the mean with SE or percentage unless otherwise specified.
Abbreviations: COPD, chronic obstructive pulmonary disease; CT, chemotherapy; ET, endocrine therapy; HS, high school; ODX, Oncotype DX (Genomic Health, Redwood City, CA); PR, progesterone receptor.
*
Compared with mastectomy.