Table A1.
Trial | Years | Treatment Arms | No. |
---|---|---|---|
MOSAIC | 1998-2001 | FU + LV v FOLFOX | 2,241 |
XELOXA | 2003-2004 | FU + LV v XELOX | 1,793 |
N0147* | 2004-2009 | mFOLFOX6 v mFOLFOX6 + Cetuximab | 3,153 |
C-07 | 2000-2002 | FU + LV v FOLFOX | 2,434 |
C-08 | 2004-2006 | mFOLFOX6 v mFOLFOX6 + bevacizumab | 2,612 |
Total ACCENT | 12,233 |
Abbreviations: ACCENT, Adjuvant Colon Cancer End Points; FOLFOX, fluorouracil, leucovorin, and oxaliplatin; FU, fluorouracil; LV, leucovorin; mFOLFOX6, modified FOLFOX 6 as infusional/bolus fluorouracil, leucovorin, and oxaliplatin; MOSAIC, Adjuvant Treatment of Colon Cancer; XELOX, intravenous oxaliplatin plus oral capecitabine; XELOXA, Adjuvant XELOX.
All patients enrolled to N0147 who received FOLFOX were included, regardless of KRAS status.