Table 2.
Univariate Analysis of Variables Predictive for Local Progression
| Variable | All Lesions | RFA | SBRT | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Treatment | |||||||||
| RFA v SBRT | 2.63 | 1.20 to 5.75 | .016 | — | — | — | — | — | — |
| Age | 1.02 | 0.98 to 1.06 | .407 | 1.02 | 0.98 to 1.06 | .439 | 1.01 | 0.91 to 1.11 | .858 |
| Tumor size | 1.36 | 1.03 to 1.80 | .029 | 1.54 | 1.13 to 2.09 | .006 | 1.21 | 0.57 to 2.54 | .617 |
| Child-Pugh score | 0.92 | 0.73 to 1.15 | .452 | 0.92 | 0.75 to 1.15 | .485 | 0.93 | 0.34 to 2.57 | .898 |
| AFP | 1.14 | 0.98 to 1.32 | .082 | 1.12 | 0.97 to 1.30 | .116 | 1.23 | 0.86 to 1.76 | .260 |
| No. prior treatments | 1.19 | 0.95 to 1.48 | .124 | 1.04 | 0.83 to 1.31 | .707 | 1.48 | 0.82 to 2.65 | .190 |
| SBRT dose | — | — | — | — | — | — | 0.91 | 0.81 to 1.02 | .110 |
NOTE. Age (per year), tumor size (per cm), Child-Pugh Score (per point), AFP (per doubling), No. prior treatments (per treatment), and SBRT dose (per Gy) were treated as continuous variables. Data in the All Lesions column has been corrected for treatment modality. Dashes indicate not applicable.
Abbreviations: RFA, radiofrequency ablation; SBRT, stereotactic body radiation therapy; HR, hazard ratio; AFP, alpha-fetoprotein.