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. 2016 May 10;3(4):e240. doi: 10.1212/NXI.0000000000000240

Figure 2. Distinct changes to immunoprofile in autoimmune thyroid disease (AITD) and multiple sclerosis (MS).

Figure 2

A linear regression with covariates age, sex, and disease duration was applied to the immune profiling results of patients with AITD and untreated patients with MS vs healthy controls, and—within patients—untreated MS vs AITD. Significant differences in the peripheral immune system of untreated patients with MS compared to controls were restricted to (A) effector memory CD8+ cells and (B) memory B cells. Significant differences compared to controls observed for patients with AITD but not patients with MS include altered proportions of (C) recent thymic emigrant CD4+, (D) Th17, (E) transitional B cells, and (F) class-switched B cells. Median with boxes indicate 25th and 75th percentile and whiskers indicate 1.5 × interquartile range.