Table 5.

Comparison of 6-Month Changes in Serum Cancer Biomarkers by Weight Loss Subgroups in the Intervention Groups, With Adjustment for Baseline Biomarker Level (N = 52)

Weight Loss (%) Over 6 Months	Δ Insulin, μU/mL, mean (SE)	Δ Glucose, mg/dL, mean (SE)	Δ CRP, mg/L, mean (SE)	Δ Leptin, ng/mL, mean (SE)	Δ Adiponectin, μg/mg, mean (SE)	Δ IL-6, pg/mL, mean (SE)*	∆ TNF-α, pg/mg, mean (SE)
< 5, n = 25	−0.59 (0.92)	−2.00 (1.70)	−0.54 (0.31)	−0.76 (2.19)	0.14 (0.95)	0.59 (0.24)	0.03 (0.11)
≥ 5, n = 27	−3.21 (0.89)	−2.96 (1.53)	−1.58 (0.30)	−11.08 (2.11)	1.44 (0.91)	−0.20 (0.24)	−0.17 (0.10)
P†	.05	.69	.02	.002	.33	.02	.19

NOTE. Twelve participants did not return for the 6-month clinic visit.

Abbreviations: CRP, C-reactive protein; IL, interleukin; TNF, tumor necrosis factor.

^*n = 51; one participant excluded due to a baseline IL-6 level that was below the lower limit of detection.

^†P for F test comparing group means.