Table 3.
Proportion of Positive Lesions Detected by 68Ga-DOTATATE PET/CT, 111In-Pentetreotide SPECT/CT, and CT Scan on the Basis of Lesions Identified by Imaging Denominator
| Lesion by Compartment | 68Ga-DOTATATE PET/CT | 111In-Pentetreotide SPECT/CT | Anatomic Imaging (CT and/or MRI) | P (68Ga-DOTATATE v 111In-Pentetreotide) | P (68Ga-DOTATATE v CT/MRI) | |||
|---|---|---|---|---|---|---|---|---|
| No. of Lesions Found (imaging denominator) | Proportion of Positive Lesions, % (95% CI) | No. of Lesions Found (imaging denominator) | Proportion of Positive Lesions, % (95% CI) | No. of Lesions Found (imaging denominator) | Proportion of Positive Lesions, % (95% CI) | |||
| Total | 847 (891) | 95.1 (92.4 to 96.8) | 275 (891) | 30.9 (25.0 to 37.5) | 404 (891) | 45.3 (37.9 to 52.9) | < .001 | < .001 |
| Pancreas | 105 (110) | 95.5 (89.4 to 98.1) | 22 (110) | 20 (12.8 to 29.8) | 59 (110) | 53.6 (42.8 to 64.2) | < .001 | < .001 |
| Liver | 396 (408) | 97.1 (93.7 to 98.7) | 170 (408) | 41.7 (31.1 to 53.1) | 233 (408) | 57.1 (44.7 to 68.7) | < .001 | < .001 |
| Bowel | 49 (51) | 96.1 (75.9 to 99.5) | 7 (51) | 13.7 (5.4 to 30.7) | 6 (51) | 11.8 (3.6 to 32.6) | < .001 | < .001 |
| Lung and mediastinum | 30 (40) | 75 (54.4 to 88.3) | 16 (40) | 40 (25.3 to 56.7) | 30 (40) | 75 (53.0 to 88.9) | .003 | 1.0 |
| Abdomen and retroperitoneal lymph node | 144 (153) | 94.1 (87.1 to 97.4) | 41 (153) | 26.8 (16.6 to 40.2) | 60 (153) | 39.2 (29.7 to 49.6) | < .001 | < .001 |
| Bone | 123 (129) | 95.3 (82.5 to 98.9) | 19 (129) | 14.7 (6.4 to 30.6) | 16 (129) | 12.4 (7.3 to 20.3) | < .001 | < .001 |
NOTE. Imaging denominator represents the sum of functional and anatomic imaging.
Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; PET, positron emission tomography; SPECT, single-photon emission computed tomography.