Skip to main content
. 2015 Dec 14;34(4):329–336. doi: 10.1200/JCO.2015.63.3826

Table 4.

Multivariable Regression Models for Disease Status

Regression Model No. of Patients Overall Mortality Failure for PFS Relapse NRM
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Disease status
 MRD-negative remission 235 1 (reference) 1 (reference) 1 (reference) 1 (reference)
 MRD-positive remission 76 3.69 (2.51 to 5.42) < .001 4.38 (3.04 to 6.33) < .001 4.17 (2.69 to 6.47) < .001 1.72 (0.93 to 3.18) .083
 Active disease 48 4.40 (2.56 to 7.55) < .001 5.30 (3.18 to 8.81) < .001 4.87 (2.50 to 9.72) < .001 1.37 (0.52 to 3.65) .530
Age (per 10 years) 1.12 (0.98 to 1.29) .089 0.98 (0.87 to 1.10) .704 0.87 (0.75 to 1.00) .050 1.27 (0.99 to 1.65) .065
Cytogenetic risk group
 Intermediate/favorable 264 1 (reference) 1 (reference) 1 (reference) 1 (reference)
 Adverse 89 0.90 (0.61 to 1.32) .583 1.00 (0.70 to 1.45) .979 1.19 (0.77 to 1.86) .430 0.66 (0.34 to 1.32) .240
Type of AML
 De novo 144 1 (reference) 1 (reference) 1 (reference) 1 (reference)
 Secondary 97 1.01 (0.73 to 1.41) .953 0.99 (0.72 to 1.35) .945 0.91 (0.62 to 1.35) .640 1.03 (0.55 to 1.93) .880
Pre-HCT karyotype
 Normalized 132 1 (reference) 1 (reference) 1 (reference) 1 (reference)
 Not normalized 85 1.48 (0.94 to 2.33) .088 1.58 (1.02 to 2.43) .039 1.26 (0.75 to 2.10) .380 1.43 (0.70 to 3.12) .360
Pre-HCT blood counts*
 Recovered 258 1 (reference) 1 (reference) 1 (reference) 1 (reference)
 Not recovered 101 0.87 (0.59 to 1.29) .490 0.86 (0.59 to 1.24) .418 0.97 (0.61 to 1.57) .910 1.08 (0.58 to 2.03) .800

NOTE. No. of events: overall mortality, n = 168 deaths; failure for PFS, n = 189 events; relapse, n = 132 relapses/disease progressions; NRM, n = 57 deaths without prior experience of relapse/disease progression.

Abbreviations: AML, acute myeloid leukemia; HCT, hematopoietic cell transplantation; HR, hazard ratio; MRD, minimal residual disease; neg, negative; NRM, nonrelapse mortality; PFS, progression-free survival; pos, positive.

*

Recovered: absolute neutrophil count ≥ 1,000/µL and platelets ≥ 100,000/µL; not recovered: absolute neutrophil count < 1,000/µL and/or platelets < 100,000/µL