Table 1. Altered gene expression upon enhancer deletion.
| Enhancer | Total number of up regulated genes (>1.5 FC) | Upregulated genes +/− 1 Mb | Total number of downregulated genes (>1.5 FC) | Downregulated genes +/− 1 Mb | Putative direct targets | Average RPKM in Controls | Fold Change | Distance from enhancer to TSS |
|---|---|---|---|---|---|---|---|---|
| E7 | 590 | 0 | 565 | 5 | FAM84B | 7.45 | 1.50 | −843 000 |
| CCAT1 | 2.79 | 1.78 | −182 000 | |||||
| CASC8 | 2.33 | 1.55 | 81 000 | |||||
| MYC | 112.3 | 2.31 | 335 000 | |||||
| PVT1 | 7.96 | 1.59 | 395 000 | |||||
| E7 (HEK293) | 166 | 0 | 295 | 1 | MYC | 28.5 | 5.10 | 335 000 |
| 18qE | 13 | 0 | 3 | 0 | N/A | N/A | N/A | N/A |
| 18qNE | 14 | 0 | 3 | 0 | N/A | N/A | N/A | N/A |
Altered gene expression upon enhancer deletion. The number of genes having >1.5 fold increase or decrease in expression in the genome and within +/− 1 Mb after deletion of each distal region is indicated. Also shown are the names of the putative direct target genes, the average RPKM values for these genes in the control cells, the fold decrease in the enhancer-deleted cells and the distance of these genes from the distal regions.