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. 2016 Jan 20;44(9):4147–4162. doi: 10.1093/nar/gkw008

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Model of co-transcriptional methylation of H3K36 and its function in heterochromatic and subtelomeric regions in fission yeast. (Left panel) In the initial step of transcription, Set2 interacts with Pol2 or other factors with unknown mechanism and promotes H3K36me2 co-transcriptionally. The output of H3K36me2 is not yet known. (Right panel) When CTD-S2 (and probably CTD-S5) is phosphorylated, Set2 changes the binding mode to favor the interaction between the Set2 SRI domain and Pol2 CTD-S2,5P, thereby promoting formation of H3K36me3. H3K36me3 directs post-transcriptional gene silencing in heterochromatin, but assists in transcriptional gene silencing in the subtelomeric region.