Table 1. (A) Standardized incidence rate in Lombardia and Denmark.

A
LOMBARDIA				DENMARK
Year	Female	Male	Total (95% CI)	Year	Female	Male	Total (95% CI)
2000	55.4	21.9	39.1 (35.5–42.7)	2000	17.6	3.5	10.7 (8.0–13.4)
2001	41.0	20.4	31.1 (27.9–34.3)	2001	18.2	5.5	12.1 (9.3–14.9)
2002	34.1	17.2	26.4 (23.4–29.3)	2002	19.5	4.6	12.3 (9.5–15.1)
2003	30.5	16.3	23.9 (21.0–26.7)	2003	21.9	4.4	13.4 (10.5–10.5)
2004	25.7	13.1	19.5 (17.0–22.0)	2004	20.0	6.2	13.1 (10.3–16.0)
2005	21.7	12.8	17.5 (15.2–20.2)	2005	18.2	5.9	12.2 (9.5–14.9)
2006	27.9	11.4	20.4 (17.7–23.1)	2006	16.3	5.1	10.9 (8.3–13.6)
2007	21.1	9.8	16.2 (13.8–18.6)	2007	14.2	3.3	8.4 (6.5–11.2)
2008	18.7	9.1	14.1 (12.0–16.2)	2008	18.7	4.3	11.7 (9.1–14.4)
2009	16.1	8.3	12.6 (10.5–14.7)	2009	13.3	4.9	9.1 (6.8–11.4)
2004–09	21.9	10.7	16.7 (14.4–19.1)	2000–09	17.7	4.7	11.4 (10.6–12.3)
B
2000	52	19	36 (33–40)		174	33	107 (99–115)
2001	90	32	62 (57–66)		178	31	108 (100–116)
2002	119	44	82 (77–88)		178	33	109 (101–117)
2003	143	56	100 (94–106)		184	35	113 (104–121)
2004	162	61	113 (106–119)		191	34	116 (108–125)
2005	177	66	123 (117–129)		197	35	120 (111–128)
2006	199	70	136 (129–143)		197	37	120 (112–129)
2007	213	74	146 (139–153)		200	35	121 (112–129)
2008	226	77	154 (146–161)		198	36	120 (112–129)
2009	234	81	160 (152–167)		203	35	122 (114–131)
2000–2009	162	58	111 (109–113)		190	34	115 (113–118)

For Lombardia, we used a 4 year washout period (2000–2004) to avoid including prevalent cases and determined a 6 year span time (from Jan 1^st 2004 to Dec 31^st 2009) with no significant variation of the Standardized Incidence Ratio (SIR). (B) Point prevalence of PBC in Lombardia and Denmark from 2000 to 2009.