Table 2. Multivariable regression analyses of associations of adipokines and HOMA-IR with thyroid hormones and TSH.
| FT4 |
FT3 |
TSH |
||||
|---|---|---|---|---|---|---|
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
| Control | ||||||
| Adiponectin | 0. 746 (0.489, 1.004) | <0.001 | −0.014 (−0.238, 0.209) | 0.899 | −0.026 (−0.108, 0.056) | 0.540 |
| Resistin | 1.320 (0.861,1.780) | <0.001 | 0.060 (−0.338, 0.459) | 0.766 | −0.018 (−0.164, 0.129) | 0.813 |
| Leptin | −0.337 (−0.882 0.208) | 0.225 | −0.663 (−1.111, −0.215) | 0.004 | 1.134 (1.018, 1.250) | <0.001 |
| HOMA-IR | −0.009 (−0.279, 0.260) | 0.947 | 0.047 (−0.177, 0.270) | 0.682 | −0.036 (−0.118, 0.046) | 0.386 |
| Hypothyroid | ||||||
| Adiponectin | 0.732 (0.399, 1.065) | <0.001 | −0.009 (−0.243, 0.225) | 0.940 | 0.060 (−0.007, 0.128) | 0.080 |
| Resistin | −1.064 (−1.586, −0.542) | <0.001 | 0.239 (−0.125, 0.602) | 0.197 | 0.004 (−0.103, 0.110) | 0.948 |
| Leptin | −0.555 (−1.165, 0.056) | 0.075 | 0.025 (−0.381, 0.432) | 0.902 | 0.631 (0.557, 0.705) | <0.001 |
| HOMA-IR | 0.104 (−0.277, 0.485) | 0. 590 | 0.352 (0.104, 0.600) | 0.006 | 0.005 (−0.067, 0.078) | 0.882 |
| Hyperthyroid | ||||||
| Adiponectin | 0.148 (−0.006, 0.303) | 0.060 | 0.117 (0.020, 0.214) | 0.018 | −0.009 (−0.036, 0.018) | 0.502 |
| Resistin | 0.903 (0.679, 1.128) | <0.001 | 0.408 (0.257, 0.558) | <0.001 | −0.081 (−0.123, −0.038) | <0.001 |
| Leptin | −0.236 (0.459, −0.014) | 0.038 | −0.161 (−0.300, −0.021) | 0.025 | 0.172 (0.204, 0.602) | <0.001 |
| HOMA-IR | −0.036 (−0.165, 0.094) | 0.588 | 0.027 (−0.054, 0.109) | 0.511 | −0.011 (−0.033, 0.011) | 0.326 |
Multivariable regression analyses were conducted with age, gender, BMI, TC, TG, HDLC and LDLC as independent variables. Analyses were conducted in control, hypothyroid and hyperthyroid group separately.