Table 2.
Overall- and Event-Free Survival Estimates from Univariable Cox Regression Models.
| Overall Survival |
Event-Free Survival |
||||||
|---|---|---|---|---|---|---|---|
| Co-variate | HR | 95%CI | p value | HR | 95%CI | p value | |
| Risk | High vs Non-high | 9.9 | 2.9, 33.4 | <0.001 | 5.3 | 2.3, 12.3 | <0.001 |
| Age | ≥18 mo vs <18 mo | 1.8 | 0.8, 4.2 | 0.147 | 2.3 | 1.2,4.8 | 0.024 |
| Stage* | 4 vs 1,2,3 or 4s | 16.5 | 3.9, 70.5 | <0.001 | 6.8 | 2.8, 16.6 | <0.001 |
| Site | Abdom vs Extra-Abd | 5.9 | 0.8, 43.9 | 0.020 | 2.5 | 0.8, 8.2 | 0.090 |
| Grade | PD vs Differentiating | 1.9 | 0.3, 14.1 | 0.535 | 0.8 | 0.3, 2.7 | 0.747 |
| UD vs Differentiating | 6.9 | 0.8, 62.0 | 0.085 | 2.1 | 0.5, 9.5 | 0.330 | |
| INPC | UH vs FH | 7.6 | 2.3, 25.7 | <0.001 | 4.9 | 2.0, 12.0 | <0.001 |
| MKI | Intermediate vs Low | 2.3 | 0.4, 13.7 | 0.363 | 1.2 | 0.3, 4.5 | 0.788 |
| High vs low | 7.9 | 1.8, 34.1 | 0.005 | 4.0 | 1.5, 10.5 | 0.005 | |
| MYCN | Amp vs Non-amp | 3.2 | 1.4, 7.1 | 0.005 | 2.3 | 1.1, 4.5 | 0.023 |
| 1p del | Present vs Absent | 5.5 | 2.2, 13.9 | <0.001 | 5.0 | 2.3, 11.3 | <0.001 |
| 17q gain | Present vs Absent | 2.9 | 1.0, 8.9 | 0.039 | 3.1 | 1.2, 8.4 | 0.014 |
| pHH3-PI§ | >0.54% vs <0.54% | 1.60 | 0.7, 3.6 | 0.254 | 1.3 | 0.6,2.5 | 0.503 |
| pHH3-PI† | >1.0% vs <1.0% | 2.6 | 1.1, 5.8 | 0.022 | 2.1 | 1.0, 4.3 | 0.039 |
HR, hazard ratio; CI, confidence interval; Abdom, abdominal; Extra-Ab, extra-abdominal; PD, poorly differentiated; UD, undifferentiated; MKI, mitosis karyorrhexis index; INPC, International Neuroblastoma Pathology Classification; UH, unfavorable histology; FH, favorable histology; Amp, amplified; Non-amp, non-amplified; pHH3, phosphohistone 3; PI, proliferation index; The numbers in bold indicate significant p values.
*
Stages 4s,1-3 combined
§
Median values were used as a cut-off
†
Threshold of 1% (~75th percentile) was used as the cut-off value.