Table 4.

Overall and Event-Free Survival Estimates from Cox Regression Models for pHH3-PI in Neuroblastomas from Children Aged Less Than 18 Months.

	Univariable Analyses						Multivariable Analyses
	Overall Survival			Event-Free Survival			Overall Survival			Event-Free Survival
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
Model 1
MKI
High vs L&I	9.5	2.0, 46.0	0.005	4.5	1.3, 15.3	0.017	8.9	1.8, 44.7	0.008	4.7	1.3, 17.0	0.016
Age (mo)
≥6 vs <6†	2.2	0.5, 8.6	0.277	1.2	0.4, 3.8	0.797	1.3	0.3, 5.4	0.718	1.0	0.2, 2.7	0.708
Model 2
pHH3-PI
High vs low*	6.7	1.7, 27.0	0.007	3.7	1.1, 12.1	0.032	6.2	1.5, 25.4	0.012	3.7	1.1, 12.5	0.033
Age (mo)
≥6 vs <6†	2.2	0.5, 8.6	0.277	1.0	0.3, 3.4	0.938	1.6	0.4, 6.4	0.537	0.9	0.3, 3.1	0.901
Model 3
pHH3-PI
High vs low*	6.7	1.7, 27.0	0.007	3.7	1.1, 12.1	0.032	4.0	0.9, 16.9	0.060	2.5	0.7, 8.9	0.143
MKI
High vs L&I	9.5	2.0, 46.0	0.005	4.5	1.3, 15.4	0.017	6.4	1.3, 32.9	0.026	3.4	0.9, 12.4	0.062

(n=42). Number of deaths = 9; Number of events (relapse) =11; MKI, mitosis karyorrhexis index; pPH3, phosphohistone 3, PI, proliferation index; HR, hazard ratio; CI, confidence interval; L&I, low plus intermediate combined.

^*A threshold of >1% (~75th percentile) was used as cut-off value.

^†Median age used as a cut-off value.