Table 3. Binding affinity and inhibitory activities of compounds 1–8.

Compound	Inhibitory activities against 11β-HSD1	Dissociation constant with 11β-HSD1
	Kd a (μM)	IC50 (μM)
1	n.b.b	n.i. c
2	n.b.	n.i.
3	82.1 ± 5.01	9.07 ± 0.61
4	n.b.	n.i.
5	420.51 ± 12.11	45.51 ± 7.82
6	513.14 ± 10.61	68.05 ± 7. 84
7	n.b.	n.i.
8	n.b.	n.i.

a The Kd value is automatic calculated by the curve fitting, and presents as means ± SD for three experiments.

b n.b. is no clear binding detected in the MST measurement.

c n.i. is no inhibition detected in the experiments (IC₅₀ > 200 μM).