Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 May 19;6:26370. doi: 10.1038/srep26370

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

The speed of fixation is equal to the inverse of the time to fixation. This plot is shown in log-log scale. (A) Chronic infections (blue symbols) have higher probability of fixation (except for the between host s_h⁰t_m⁺ model) while acute infections (red symbols) have higher speed of fixation. (B) Superinfection (filled symbols) greatly increases both the probability and the speed of fixation in chronic models containing within-host advantage but not between-host disadvantage (s_h⁺t_m⁰ and s_h⁺t_m⁺), while decreasing speed of fixation and increasing probability of fixation in between-host model (s_h⁰t_m⁺). Identical model types with and without superinfection are joined by a line. (C) The mixed model, with both acute and chronic infections in the same population, increases both speed of and probability of fixation of mutations occurring in chronic infections (the values shown here are from the mixed model with 50% chronic infections). The effect of superinfection in the mixed model is similar to that in the chronic-infection only model. Pink and cyan indicate the mixed model with a beneficial mutation occurring in acute and chronic patients, respectively.