Table 3.

Associations of maximum adolescent use and late-onset cannabis use with anxiety disorder identified in 1756 cohort participants (mean age 29 years)^a.

Continuity in cannabis use from adolescence to 29 years			Anxiety disorder at 29 years (wave 9) (n = 199)
Maximum adolescent use (waves 2-6)	Use at 29 years (wave 9)	N b	Adjusted for background factors		Further adjusted for concurrent alcohol and other illicit substance use at 29 years		Further adjusted for any adolescent anxiety/depression (CIS-R>11)
			ORc	95% CI	ORd	95% CI	ORe	95% CI
None, <weekly	None	1173	1		1		1
Weekly+	None	97	2.0	1.1 to 3.7	2.2	1.1 to 4.2	1.8	0.96 to 3.5
None, <weekly	Occasional-weekly	288	1.8	1.2 to 2.8	2.1	1.3 to 3.3	2.0	1.2 to 3.3
Weekly+	Occasional-weekly	79	1.4	0.60 to 3.5	1.7	0.67 to 4.2	1.5	0.58 to 3.7
None, <weekly	Daily	85	2.2	0.91 to 5.2	2.4	0.98 to 5.8	2.5	1.0 to 6.1
Weekly+	Daily	35	3.1	1.2 to 8.3	3.8	1.3 to 11	3.2	1.1 to 9.2

^aTable derived from Degenhardt et al.³⁵

^bAll estimates obtained by averaging across the imputed datasets.

^cOdds ratios from multivariable logistic regression models adjusted for background factors: sex, nonmetropolitan school location, low parental education, parental divorce/separation by wave 6.

^dOdds ratios from multivariable logistic regression models adjusted for background factors and, at 29 years, substance use: high-risk alcohol use in the past week and other illicit substance use (any of amphetamine, cocaine, or ecstasy use in the past year).

^eOdds ratios from multivariable logistic regression models adjusted for background factors, other concurrent substance use, and any adolescent anxiety and depression symptoms measured using the revised Clinical Interview Schedule (CIS-R) (waves 2 to 6).