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MRI of BGC-823 tumor-bearing mice. Mice received 1) gadolinium-diethylene triamine pentaacetate (Gd-DTPA), 2) anti-epidermal growth factor receptor (EGFR)-DTPA-Gd, or 3) anti-EGFR-internalizing arginine-glycine-aspartic acid (iRGD)-DTPA-Gd injections via the tail vein at different time points. (A) Precontrast, (B) 15 min, (C) 30 min, (D) 1 h, (E) 2 h, and (F) 3 h.
